Home Chemistry Heterocyclic Building Blocks Tetrahydrofurans 1,3-Dihydrobenzo[C][1,2]Oxaborole
Oxidation: 1,3-Dihydrobenzo[c][1,2]oxaborole can undergo oxidation reactions, typically involving the boron atom. Oxidation can convert the boron atom into a boronic acid or boronate ester, depending on the oxidizing agent used.
Borylation Reactions: This compound can be used as a boron source in borylation reactions. For example, it can react with various electrophiles in the presence of appropriate catalysts to introduce boron-containing groups onto organic molecules.
Cross-Coupling Reactions: 1,3-Dihydrobenzo[c][1,2]oxaborole can participate in cross-coupling reactions, especially Suzuki-Miyaura coupling, which involves the reaction of a boron-containing compound with an organic halide or pseudohalide (e.g., aryl bromide or aryl chloride) to form a new carbon-carbon bond.
Hydrolysis: In the presence of water or aqueous acids, the boron-oxygen bond in 1,3-dihydrobenzo[c][1,2]oxaborole can be cleaved through hydrolysis, leading to the formation of boronic acids or their derivatives.
Reduction: It can also undergo reduction reactions, where the boron atom may be converted to a borane or a boron hydride compound.
Substitution Reactions: Depending on the functional groups present on the benzene ring, 1,3-dihydrobenzo[c][1,2]oxaborole can undergo substitution reactions, such as nucleophilic aromatic substitution, where substituents on the ring are replaced by other functional groups or atoms.
Complexation: 1,3-Dihydrobenzo[c][1,2]oxaborole can form complexes with Lewis acids or other molecules, which can impact its reactivity and selectivity in various reactions.
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5-Fluoro-6-nitrobenzo[c][1,2]oxaborol-1(3H)-ol
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6-Amino-5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol
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5-(Trifluoromethyl)benzo[c][1,2]oxaborol-1(3H)-ol
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7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol
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6-Aminobenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride
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1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxylic acid
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